Preclinical Safety Evaluation of Swietenia Mahagoni Leaf in Wistar Rats
نویسنده
چکیده
Objective: The study evaluates the acute toxicity of the Swietenia Mahagoni leaf in rats of Wistar strain. Methods: Whole leaf powder at a maximum allowable dose (as per OECD guidelines (2000 mg Kg-1
منابع مشابه
Comparative study of the effect of ethanolic extract of Swietenia mahagoni seeds with rosiglitazone on experimentally induced diabetes mellitus in rats.
The study was performed to compare the blood glucose lowering effect of Swietenia mahagoni seeds with an oral antidiabetic drug, rosiglitazone in experimentally induced diabetic rats. Twentyfour healthy Long Evans Norwegian strain of rats were included in the study and divided into four groups (A, B, C and D) comprising 6 rats each. Group A (control group) received standard rat food for 14 days...
متن کاملIn Vivo Antihypercholesterolemic Potential of Swietenia mahagoni Leaf Extract
The present investigation aims to evaluate antihypercholesterolemic potential of Swietenia mahagoni leaf aqueous extract (MAE) in diet-induced hypercholesterolemic rat model. In the study, Wistar albino rats (170-220 g) were segregated into 5 groups; all the groups except normal control group were given high fat diet to induce hypercholesterolemia. After induction of cholesterolemia, normal con...
متن کاملAntidiabetic Potentiality of the Aqueous-Methanolic Extract of Seed of Swietenia mahagoni (L.) Jacq. in Streptozotocin-Induced Diabetic Male Albino Rat: A Correlative and Evidence-Based Approach with Antioxidative and Antihyperlipidemic Activities
Antidiabetic, antioxidative, and antihyperlipidemic activities of aqueous-methanolic (2 : 3) extract of Swietenia mahagoni (L.) Jacq. (family Meliaceae) seed studied in streptozotocin-induced diabetic rats. Feeding with seed extract (25 mg 0.25 mL distilled water(-1)100 gm b.w.(-1)rat(-1) day(-1)) for 21 days to diabetic rat lowered the blood glucose level as well as the glycogen level in liver...
متن کاملPharmacognosy of Swietenia Mahagoni Bark Drug
Swietenia mahagoni Jacq. (native to tropical America), a common avenue tree of India, yields a bark drug, used as antipyretic, bitter tonic, astringent, and occasionally as a substitute for Cinchona. The district characteristics of the species are : blackish brown colour; cracks and fissures with both clean cut and thick recurved edges; irregular wrinkles; splintery and fibrous fractures; bitte...
متن کاملIn Vitro Anthelmintic Activity of Swietenia Mahagoni Seed Extracts against Pheritima Posthuma
Swietenia mahagoni belongs to Meliaceae family, native to West Indies. The plant is commonly known as “mahogani.’’ This timber tree is mainly cultivated in tropical zones such as India, Malaysia and Southern China. In the present study, Crude aqueous, chloroform and acetone extracts of Swietenia mahagoni seeds were evaluated for in-vitro anthelmintic activity on the Indian adult earthworms Pher...
متن کامل